Risk factors for advanced resuscitation in term and near-term infants: a case-control study.

OBJECTIVE: (1) To determine which antepartum and/or intrapartum factors are associated with the need for advanced neonatal resuscitation (ANR) at birth in infants with gestational age (GA) ≥34 weeks. (2) To develop a risk score for the need for ANR in neonates with GA ≥34 weeks. DESIGN: Prospective multicentre, case-control study. In total, 16 centres participated in this study: 10 in Argentina, 1 in Chile, 3 in Brazil and 2 in the USA. RESULTS: A case-control study conducted from December 2011 to April 2013. Of a total of 61 593 births, 58 429 were reported as an GA ≥34 weeks, and of these, only 219 (0.37%) received ANR. After excluding 23 cases, 196 cases and 784 consecutive birth controls were included in the analysis. The final model was generated with three antepartum and seven intrapartum factors, which correctly classified 88.9% of the observations. The area under the receiver operating characteristic (AROC) performed to evaluate discrimination was 0.88, 95% CI 0.62 to 0.91. The AROC performed for external validity testing of the model in the validation sample was 0.87 with 95% CI 0.58 to 0.92. CONCLUSIONS: We identified 10 risk factors significantly associated with the need for ANR in newborns ≥34 weeks. We developed a validated risk score that allows the identification of newborns at higher risk of need for ANR. Using this tool, the presence of specialised personnel in the delivery room may be designated more appropriately.

Hipotermia terapéutica: programa para prevención del daño neurológico de la encefalopatía hipóxico isquémica en Buenos Aires / THERAPEUTIC HYPOTHERMIA: A MODEL TO PREVENT NEUROLOGIC DAMAGE BY ISCHEMIC HIPOXIC ENCEPHALOPATHY

Introducción: La hipotermia terapéutica (HT) es el estándar de cuidado para la encefalopatía hipóxico-isquémica (EHI). El servicio de neonatología implemento el programa de HT en el marco de la red perinatal de la Ciudad de Buenos Aires (RPCABA). Objetivos: Describir la implementación del programa de hipotermia en RPCABA. Reportar la mortalidad, complicaciones y efectos adversos asociados al tratamiento. Métodos: La implementación del programa se realizó en etapas: 1) 2009- 2010 Capacitación y entrenamiento en el uso del equipamiento. 2) 2010 hasta la actualidad: Tratamiento y seguimiento para los pacientes con EHI moderada o grave. Resultados: Hasta Marzo de 2017, 65 neonatos recibieron HT (7 con hipotermia corporal total y los 58 restantes hipotermia activa selectiva), 49 paciente fueron clasificados según la Escala Sarnat & Sarnat como EHI moderada y 16 como EHI grave. Conclusiones: Fue factible implementar el programa en nuestra unidad, auditarlo para mejorarlo y sostenerlo en el tiempo. El sistema de traslado pudo responder ante la activación del "código de hipotermia", cumpliendo tiempos, sosteniendo el tratamiento y el monitoreo adecuado. Creemos necesario mejorar la identificación de neonatos con diagnóstico de EHI en RPCABA. Se necesita nueva capacitación para evitar el subdiagnóstico de esta patología en los centros de nivel 2

Therapeutic hypothermia (TH) is nowadays the gold standard of care for the treatment of hypoxic- ischemic encephalopathy (HIE) in developed countries. The term encephalopathy refers to a diffuse disturbance of brain function, resulting in behavioral changes, altered consciousness or seizures. The brain is particularly vulnerable to even brief interruptions of blood flow or oxygen supply. If the brain´s oxygen supply is insufficient, consciousness is lost rapidly. If oxygenation is restored immediately, consciousness returns without sequelae. However, if oxygen deprivation lasts longer than 1 or 2 minutes, signs of an encephalopathy may persists for hours or permanently. Total ischemic anoxia lasting longer than about 4 minutes usually results in severe irreversible brain damage. The aim of the present report was to describe the implementation of the hypothermia program in a model for the perinatal system at the City of Buenos Aires, with the equipment Cool Cap® for selective hypothermia, and the equipment CFM Olympic 6000® and CFM OMB from Medix® by Natus®, these two to monitoreate the cerebral function. The results obtained are referred, with special consideration to mortality, complications and adverse effects associated with the treatment.

Implementation in Buenos Aires City of a program to prevent neurological damage caused by hypoxic-ischemic encephalopathy: Therapeutic hypothermia.

Therapeutic hypothermia is the standard of care for hypoxic-ischemic encephalopathy (HIE). This treatment was implemented at a regional level by the perinatal network of the City of Buenos Aires. The following are the objectives of this article: 1. To describe the implementation of the network's hypothermia treatment program; 2. To report treatment-associated complications, adverse events and mortality. The program was implemented in stages: 1) 2009-2010. Training and instruction on how to use the equipment. 2) 20102014. Treatment and follow-up of patients with moderate or severe HIE. Up to October 2014, 27 newborn infants received hypothermia treatment with moderate (n= 15) and severe (n= 12) HIE. None of the patients died during treatment. Three newborn infants were lost to follow-up. Among the 16 survivors older than one year old, three have severe neurological disability. Program implementation was plausible. It is imperative to train health care providers on how to identify patients with HIE.

[Body mass index and blood pressure at one year of age by birth weight, weight gain and early feeding patterns]. / Índice de masa corporal y tensión arterial al año de edad según peso al nacer, ganancia de peso y patrones de alimentación temprana.

INTRODUCTION: Abnormal early growth patterns have been associated with overweight and other related diseases along the life course. OBJECTIVE: To analyze the association between changes in growth patterns and nutrition status during the second semester of life and blood pressure (BP), according to weight for gestational age (GE), and early dietary patterns, in a sample of healthy children. METHODS: Prospective study from a sample of healthy children followed between 6-12 months of age, between 10/07 and 3/08 at Hospital P. Elizalde. Gender, weight and gestational age at birth, weight, height and body mass index (BMI, WHO ref.) at 6, 9 and 12 months, length of breastfeeding, and blood pressure (BP) at 12 months of age were assessed. RESULTS: One hundred twenty infants were follow- up. Variation in standardized BMI between 6-12 months of age is the main predictor of BMI at 12 months of age (R2 0.12; Coef b 0.34; error estándar 0.11; p 0.006). The interaction term between length of breastfeeding and small for gestational age is the main predictor of changes in BMI between 6-12 months of age (R2 0.11; Coef b -0.15; error estándar 0.04, p < 0.001). Each standardized unit increment in BMI implies an increase of 1.76 mmHg in diastolic blood pressure at one year. CONCLUSION: Length of gestation, birth weight and early feeding patterns are associated with weight gain during the first year of life, which is linked at the same time to BMI and BP. The positive change in BMI was associated with shorter duration of breastfeeding and this in turn to higher blood pressure at one year.

Índice de masa corporal y tensión arterial al año de edad según peso al nacer, ganancia de peso y patrones de alimentación temprana / Body mass index and blood pressure at one year of age by birth weight, weight gain and early feeding patterns

Introducción. Las alteraciones en el crecimiento temprano se asocian con diferentes condiciones adversas en el curso de la vida. Objetivo. Analizar la asociación entre variación en el estado nutricional durante el segundo semestre de la vida y tensión arterial al año de vida, según condiciones al nacer y patrones alimentarios en una cohorte de niños sanos. Población y métodos. Estudio prospectivo de una cohorte de niños sanos seguidos entre los 6 y 12 meses de edad, entre octubre/2007 y marzo/ 08 en el Hospital Pedro de Elizalde. Se valoró peso y edad gestacional al nacer, peso, talla e índice de masa corporal (IMC) a los 6, 9 y 12 meses, duración de lactancia materna y tensión arterial a los 12 meses de edad. Resultados. Se estudiaron 120 niños que completaron el seguimiento. La variación en el valor estandarizado de IMC entre 6-12 meses de edad constituye el único predictor de IMC a los 12 meses (R2 0,12; Coef b 0,34; error estándar 0,11; p 0,006). La interacción entre duración de lactancia materna y bajo peso para la edad gestacional constituye el principal predictor de la variación de IMC (R2 0,11; Coef b -0,15; error estándar 0,04, p < 0,001). El incremento en una unidad estandarizada de IMC al año implica un incremento en 1,76 mmHg de tensión arterial diastólica. Conclusión. El aumento en el IMC se vinculó con menor duración de la lactancia materna. Tal variación se asocia con mayor IMC al año de edad y éste, a su vez, con mayor tensión arterial.

Introduction. Abnormal early growth patterns have been associated with overweight and other related diseases along the life course. Objective. To analyze the association between changes in growth patterns and nutrition status during the second semester of life and blood pressure (BP), according to weight for gestational age (GE), and early dietary patterns, in a sample of healthy children. Methods. Prospective study from a sample of healthy children followed between 6-12 months of age, between 10/07 and 3/08 at Hospital P. Elizalde. Gender, weight and gestational age at birth, weight, height and body mass index (BMI, WHO ref.) at 6, 9 and 12 months, length of breastfeeding, and blood pressure (BP) at 12 months of age were assessed. Results. One hundred twenty infants were follow- up. Variation in standardized BMI between 6-12 months of age is the main predictor of BMI at 12 months of age (R2 0.12; Coef b 0.34; error estándar 0.11; p 0.006). The interaction term between length of breastfeeding and small for gestational age is the main predictor of changes in BMI between 6-12 months of age (R2 0.11; Coef b -0.15; error estándar 0.04, p < 0.001). Each standardized unit increment in BMI implies an increase of 1.76 mmHg in diastolic blood pressure at one year. Conclusion. Length of gestation, birth weight and early feeding patterns are associated with weight gain during the first year of life, which is linked at the same time to BMI and BP. The positive change in BMI was associated with shorter duration of breastfeeding and this in turn to higher blood pressure at one year.